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Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

Exploring new ovarian cancer treatments with Trastuzumab Deruxtecan and Bevacizumab.

Recruiting
18 years and older
Female
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is focused on treating advanced ovarian cancer with two medicines: Trastuzumab Deruxtecan (*T-DXd*) and Bevacizumab. The goal is to see if using them together is more effective than Bevacizumab alone. Ovarian cancer is when cells in the ovaries grow out of control. This study is for those whose cancer shows a protein called HER2. First, a small group will test the safety of both medicines together. If successful, more people will join for further testing.

  • The study requires adult participants aged 18 or older.
  • Participants must have previously used Bevacizumab with chemotherapy.
  • Doctors will check for HER2 protein and other factors to ensure eligibility.

Those with non-epithelial ovarian cancer or certain genetic changes (like BRCA) can’t join. Risks include allergic reactions and heart problems. Participants must be aware of their medical history, especially heart issues or past strokes. Talk to your doctor to see if this study is right for you.

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Study details
    Ovarian Cancer

NCT06819007

Daiichi Sankyo

25 April 2026

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