This study is testing a new medicine called **LY35327021** to see if it helps with *nausea* (feeling like you're going to throw up) and *vomiting* (throwing up) caused by *chemotherapy* (a strong medicine used to treat cancer). The study will last about **2 months**. **Eligibility**: To join, you should be new to chemotherapy and about to start a specific type of it. You need to be fairly active, with an ECOG score between 0 and 2, which means you can do most of your daily activities. However, you cannot join if you have untreated brain cancer, uncontrolled diabetes, heart problems, or if you are pregnant or breastfeeding. You also can't join if you're already on certain medicines that stop nausea, or if you've been part of another study recently. **Key Points**: - The study lasts about 2 months with multiple parts. - You can't join if you have certain health issues or are on specific medicines. - The medicine is being tested for safety and effectiveness in controlling nausea and vomiting from chemotherapy. **Please consider these points carefully before deciding to participate.**