Dry Eye Disease (DED) is a condition where your eyes don't make enough tears or the right type of tears, leading to discomfort. This study is testing a new eye drop (GRF312 5%) to see if it's safe and helps people with DED. Participants must be adults who can use eye drops by themselves, and they should have a history of using over-the-counter artificial tears. People with certain autoimmune diseases like rheumatoid arthritis can join if they meet other rules.

Key Points:

• The study will take place at multiple sites and involves using eye drops as part of the test.
• Participants must attend all required visits and follow instructions throughout the study.
• There are many rules about what medicines and treatments you cannot have before or during the study.

Participants with severe eye infections, certain eye surgeries, or serious health issues cannot join. If you have questions about joining, discuss them with the study team or your doctor to ensure it's right for you.