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NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

Join a study to test NBI-1065845 for major depression help.

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18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

Study Purpose: This study tests a new medicine, NBI-1065845, to see if it helps people with Major Depressive Disorder (MDD) feel better when added to their current medicine. A placebo, which looks like a real medicine but isn’t, is used to compare the effects.

Who Can Join: People with MDD who haven't responded well to their current depression pills can join. They must continue taking their current pills for at least 8 weeks and score high on a test called the Hamilton Depression Rating Scale (HAM-D17). People with other main psychiatric issues or high risk of harming themselves or others cannot join.

  • **Study Duration:** Participants will need to take part in the study for the entire duration set by the researchers.
  • **Compensation:** Some form of compensation may be provided for participating in the study.
  • **Risks:** Participants may experience side effects or no improvement in symptoms.

This study aims to find better ways to help people with depression who haven't felt better with usual treatments.

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Study details
    Major Depressive Disorder

NCT06911112

Neurocrine Biosciences

7 March 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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