Sjogren's Disease (SjD) is a condition where the body's defense system attacks its own glands that make moisture, like saliva and tears. The study is testing a new medicine called nipocalimab to see if it helps people with moderate to severe SjD feel better and is safe to use.

To join, you must be 18 or older, have SjD according to specific guidelines, and have a score of at least 5 on a test called ClinESSDAI. You cannot join if you have severe health issues, allergies to nipocalimab, or other serious immune problems.

• The study involves two similar tests where you might get either nipocalimab or a placebo (a fake treatment).
• It is important to be medically stable and have no major health issues.
• No pregnancies allowed during the study; tests will be conducted to confirm.

The study will check how well the medicine works and monitor for any side effects. Participants should consider the time commitment and possible risks before joining.