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A Safety and Efficacy Study of One-time SAR402663 in Adults With Neovascular Age-related Macular Degeneration

Study on SAR402663 for age-related macular degeneration treatment.

Recruiting
50-90 years
All
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)
Study Overview: This study looks at how safe and effective SAR402663 is for people with a kind of eye disease called neovascular age-related macular degeneration (nAMD). nAMD is a condition where new, abnormal blood vessels grow under the retina, which can harm vision. The study involves a one-time injection of SAR402663 into one eye. Study Parts: - Part I: Different doses are tested to find the best one. - Part II: People get one of two doses, chosen based on Part I results. Follow-Up: After the injection, participants will have regular check-ups for 12 months. Then, they’ll be monitored for up to 5 years to see how safe and effective the treatment remains.
  • Participants: Must be 50-90 years old and have previously used anti-VEGF treatments.
  • Commitment: Involves regular visits over 5 years for eye assessments.
  • Risks: Those with recent eye infections, uncontrolled glaucoma, or other specific conditions cannot join.
This summary doesn't cover everything, so talk to your doctor if you're interested in joining.
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Study details
    Neovascular Age-related Macular Degeneration

NCT06660667

Sanofi

7 March 2026

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