Overview
Overview: The goal of this study is to use electroencephalography (EEG) to learn more about how children and adults with MECP2 disorder (Rett syndrome) process sensory information. By understanding these brain responses, our goal is to identify EEG-based biomarkers that could be used to track development and measure responses to potential future treatments.
Description: Participation in this study is voluntary and involves the participant completing an EEG, which is a safe and non-invasive way to record brain activity. We would also ask a parent or caregiver to complete questionnaires and an interview assessment on behalf of their child. There are no direct benefits to participating in this study, but the information gained may help improve our understanding of MECP2 disorder. Study participants will be paid $18 per hour for their time.
Terms: The goal of this study is to understand how individuals with MECP2 disorder (Rett syndrome) process sensory information. Study visits involve the participant completing an electroencephalogram (EEG) while listening to sounds through headphones. Our goal is to understand more about how individuals with MECP2 disorder perceive and think about sound information. This study also aims to identify EEG measures that may be useful in assessing cognition in future clinical trials.
Eligibility
Individuals aged 2 years or older with a genetically confirmed MECP2 mutation and diagnosis of classic Rett syndrome. Must be past the regression stage of their disease, have no hearing impairment, or have any genetic/neurological diagnoses in addition to Rett syndrome.