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Comparing Radiation Therapy to Usual Care for Patients With High-Risk Bone Asymptomatic Metastases, PREEMPT Trial

Comparing radiation therapy and usual care for bone metastases.

Recruiting
18 years and older
All
Phase 3
This study is about comparing **Radiation Therapy** with usual care for cancer patients who have high-risk bone metastases. **Bone metastases** are cancerous growths in bones that may not currently cause symptoms but have a higher risk of leading to complications like fractures or needing surgery. Radiation therapy uses powerful x-rays to target and kill cancer cells. The study is trying to find out if adding radiation therapy to usual care can reduce bone-related problems better than usual care alone. **Key Points:** - **Duration:** Radiation treatment lasts up to 5 days; follow-ups are at 3, 6, 12, and 24 months. - **Participation:** Patients can join if they have high-risk bone metastases and meet other criteria. - **Risks and Benefits:** Potential benefits include fewer bone problems; risks include side effects from radiation. Patients will be split into two groups: one will receive the usual cancer treatment and the other will get additional radiation therapy. The goal is to see which approach works better in preventing complications. Participants will be monitored to track their health and quality of life.
Study details
    Metastatic Malignant Neoplasm in the Bone
    Metastatic Malignant Solid Neoplasm

NCT06745024

NRG Oncology

7 March 2026

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