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Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

Testing different drug combinations for younger patients with risk AML.

Recruiting
18-59 years
All
Phase 2

This study is for young patients with a type of blood cancer called acute myeloid leukemia (AML). Doctors are testing different drug combinations to see which works best. The drugs include:

  • Cytarabine and Daunorubicin: These drugs can stop cancer cells from growing by interfering with DNA, the material in cells that carries genetic information.
  • Venetoclax: This medicine blocks a protein that helps cancer cells survive.
  • Azacitidine: This drug activates genes that fight tumors, helping to stop cancer growth.

The study goal is to find out if adding venetoclax to the treatment makes it more effective. Patients are divided into three groups, each getting a different treatment combination. Doctors will check the cancer's response through blood and bone marrow tests. The study lasts for 2 years.

  • Key Points:
  • Participation requires regular hospital visits for treatment and testing.
  • Potential side effects from the drugs will be monitored.
  • Participants must be between 18-59 years old and meet specific health criteria.
Study details
    Acute Myeloid Leukemia

NCT05554393

National Cancer Institute (NCI)

7 March 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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