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Restarting Triple Therapy With Robust Monitoring for Adverse Events (RETRIAL)

Restarting three-drug treatment with careful monitoring for side effects.

Recruiting
6 years and older
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

RETRIAL is a study for people with Cystic Fibrosis (PWCF), aged 6 and up, who had side effects from their previous medication, elexacaftor/tezacaftor/ivacaftor (ETI). These side effects could be mental health issues like depression or liver problems. The study looks at starting a new treatment called vanzacaftor/tezacaftor/deutivacaftor (VTD) and how people react to it. Participants will be closely watched for any adverse events, which are unexpected or harmful reactions.

  • Study Length: Participants need to delay the start of VTD for a short time to complete initial assessments.
  • Requirements: Participants must have access to a smart device for surveys and be English-speaking.
  • Eligibility: Participants must have experienced issues with ETI and plan to take VTD.

It's important to note that participants cannot join if they are pregnant, on any transplant list, or have severe liver disease. Caregivers of young participants under 12 can also be involved to help with daily diaries and surveys.

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Study details
    Cystic Fibrosis

NCT06683092

Boston Children's Hospital

7 March 2026

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