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A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

Comparing two treatments for endometrial cancer in a clinical trial.

Recruiting
18 years and older
Female
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for people with advanced or recurrent endometrial cancer (EC), which is a cancer starting in the uterus. Researchers want to know if a combination of two medicines, sacituzumab tirumotecan (sac-TMT) and pembrolizumab, helps people live longer without cancer getting worse compared to just pembrolizumab. Sac-TMT is an antibody drug conjugate (ADC) that targets cancer cells to destroy them. The study begins with six cycles of treatment over 18 weeks, and if the cancer doesn't worsen, participants will continue with either both medicines or just pembrolizumab.

  • Participants may have advanced EC that hasn’t been treated with chemotherapy except under specific conditions.
  • They should not have certain other types of cancer or severe eye or inflammatory bowel diseases.
  • Participants should not have uncontrolled heart or blood vessel diseases.

Eligibility requires a confirmed diagnosis of EC that is proficient mismatch repair (pMMR), meaning certain normal proteins are present in cancer cells. Key exclusions are having certain other cancers, severe eye conditions, inflammatory bowel diseases, or uncontrolled cardiovascular issues.

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Study details
    Endometrial Cancer

NCT06952504

Merck Sharp & Dohme LLC

7 March 2026

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