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A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

Exploring Ibuzatrelvir for COVID-19 in severely immunocompromised adults.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for adults with COVID-19 who have weak immune systems, called immunocompromised. Being immunocompromised means it's harder for your body to fight off infections. The study aims to test a medicine called Ibuzatrelvir, alone and with another medicine called Remdesivir to see which treatment works best. Remdesivir is given through an IV (a tube into a vein) and Ibuzatrelvir is taken by mouth.

Participants need to have a confirmed COVID-19 infection and have shown symptoms in the last 5 days. They must be severely immunocompromised due to reasons like blood cancers or organ transplants.

  • The study lasts about 24 weeks with approximately 10 clinic visits.
  • Participants will undergo blood work, nose swabs, and fill out questionnaires.
  • All participants will receive active treatment, either Ibuzatrelvir, Remdesivir, or both.

Exclusions include severe COVID-19 needing oxygen, kidney failure, liver disease, or recent use of other COVID-19 treatments. Pregnant or breastfeeding women can't join. This research will help see if the new medicine is safe and effective in treating COVID-19 for those with weak immune systems.

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Study details
    COVID-19 Infection

NCT07013474

Pfizer

7 March 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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