Image

A Study of CC-97540 (BMS-986353 or Zola-cel), CD19-Targeted NEX-T CAR T Cells, in Participants With Active SLE Despite Immunosuppressants (Breakfree-SLE)

Testing new CAR T cell therapy for SLE patients not responding to treatment.

Recruiting
16 years and older
All
Phase 2

This study is testing a new treatment called **CC-97540** (also known as _Zola-cel_), for people with active **systemic lupus erythematosus (SLE)**, which is a disease where the immune system attacks its own body. The study is for people whose SLE is not getting better with current medicines like **glucocorticoids** (steroids) and at least two other medicines that help calm the immune system.

To join the study, you need to have SLE, not be getting better with your current medicines, and have active disease. If you have other serious health problems or have had certain types of cancer in the past two years, you may not be able to join. You also cannot join if you've had certain types of therapies like CAR T cell therapy or organ transplants before.

  • Study Duration: Must use certain medicines for at least 3 months.
  • Risks: Cannot have other serious health conditions.
  • Requirements: Cannot have received live vaccines recently.
Study details
    Lupus Erythematosus
    Systemic
    Lupus Nephritis

NCT07015983

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

18 April 2026

Step 1 Get in touch with the nearest study center
We have submitted the contact information you provided to the research team at {{SITE_NAME}}. A copy of the message has been sent to your email for your records.
Would you like to be notified about other trials? Sign up for Patient Notification Services.
Sign up

Send a message

Enter your contact details to connect with study team

Investigator Avatar

Primary Contact

  Other languages supported:

First name*
Last name*
Email*
Phone number*
Race
Ethnicity
Other language

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.