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Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

Trying new treatments for high-risk neuroblastoma patients.

Recruiting
365-30 years
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This trial is for children and young people with high-risk neuroblastoma, a type of cancer. The study tests treatments to see if adding iobenguane I-131 or lorlatinib to standard therapy can improve survival rates. Iobenguane I-131 is a radioactive drug that targets cancer cells, while lorlatinib blocks enzymes that help cancer cells grow.

  • Participation involves: Receiving medicine through IV and undergoing regular scans and tests.
  • Study duration: Follow-ups occur for up to 5 years after treatment.
  • Potential risks: Side effects may occur, including changes in organ functions or behavior.

Note: Eligibility includes specific age and health criteria, and participants must not be pregnant or breastfeeding. The study is closed for some arms, meaning participants cannot join those parts anymore.

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Study details
    Ganglioneuroblastoma
    Ganglioneuroblastoma
    Nodular
    Neuroblastoma

NCT03126916

Children's Oncology Group

14 March 2026

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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