Study Overview: This study is for people with advanced pancreatic cancer that cannot be removed by surgery. After 4-6 months of initial chemotherapy, researchers want to see if higher doses of radiation therapy (high-energy X-rays) can help these patients live longer compared to usual care, which might include more chemotherapy, watching the cancer, or regular lower-dose radiation. The higher dose might work better because it gives more powerful treatment to the cancer in a shorter time.
- Study Length: Follow-up every 3 months for 2 years, then once a year for 3 more years.
- Procedures: Requires CT/MRI scans, blood samples, and tumor biopsies.
- Radiation Treatment: High-dose radiation over fewer visits compared to standard therapy.
Eligibility: Participants must have had 4-6 months of specific chemotherapy, be 18 years or older, and meet certain health criteria. They should not have had overlapping radiation in the past, and must show at least stable disease before joining. Pregnant/nursing women and those with severe heart issues are not eligible.