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Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

Exploring new treatment options for recurrent brain cancer.

Recruiting
18 years and older
All
Phase 3

This study tests a new way to treat recurrent glioblastoma, a type of brain cancer. The blood-brain barrier (BBB) is like a shield around the brain that blocks harmful substances, but it also stops many medicines from reaching the brain. SonoCloud-9 (SC9) is a device using sound waves to open the BBB so more medicine can reach the tumor. Carboplatin is a chemotherapy used to treat cancer, but it struggles to cross the BBB. This study will see if using SC9 with carboplatin helps more medicine reach and treat the brain tumor effectively.

  • Length of Study: Participation requires multiple visits.
  • Risks: There are side effects from carboplatin and risks from opening the BBB.
  • Compensation: Participants may receive compensation for their time.

To join, you must have certain medical criteria, like a specific type of glioblastoma and good health otherwise. You cannot join if you have other serious health issues or are pregnant. Understanding the details and giving consent is crucial. The study aims to improve drug delivery to the brain and potentially offer better treatment for those with recurrent glioblastoma.

Study details
    Glioblastoma
    Recurrent Glioblastoma
    GBM

NCT05902169

CarThera

12 September 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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