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A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

Researching Axatilimab and steroids for chronic graft-versus-host disease.

Recruiting
12 years and older
All
Phase 3

This study is looking at how well a medicine called axatilimab works compared to a placebo (a “fake” treatment) when used with corticosteroids to treat a condition called chronic graft-versus-host disease (cGVHD). cGVHD happens when donor cells attack the patient's body after a stem cell transplant. To join, you must be at least 12 years old and have new moderate or severe cGVHD needing treatment. You must not have had more than one stem cell transplant or have certain infections or diseases.

  • Study Duration: The study involves various visits over a period, but it doesn't specify the exact length.
  • Participation: Participants will receive either axatilimab or a placebo along with corticosteroids.
  • Risks: There are risks like uncontrolled infections or other health issues that might exclude you from participating.

It's important to discuss with your doctor if this study might be right for you, considering the requirements and your health condition.

Study details
    Chronic Graft-versus-host-disease

NCT06585774

Incyte Corporation

7 March 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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