This study aims to identify special biological indicators, called **biomarkers**, to determine which **diabetic foot ulcers (DFUs)** have a better chance of healing. **Diabetic foot ulcers** are open sores or wounds on the feet that are prone to infection and heal slowly. This study does not involve any specific treatments or medications but instead collects various samples, like blood and wound fluid, to help understand wound healing better. Participants, who must be 18 or older and have diabetes with an open foot ulcer, will have regular check-ups. These visits happen every two weeks for the first month, then monthly, until the wound heals or up to 52 weeks. If the wound heals before 52 weeks, there will be follow-ups at weeks 52 and 78 to check if the ulcer comes back. **Key Points:** - Participation lasts up to 78 weeks with regular visits. - No experimental treatments are given; it's observational. - Samples like blood or wound fluid are collected during visits. To join, participants must sign a consent form and meet certain health criteria. However, those in other DFU trials recently or undergoing specific treatments may not be eligible. Eligibility: Must sign consent, be 18+, have diabetes and an open foot ulcer. Exclusion: Recent DFU trial participation, radiation/chemotherapy, or severe foot conditions.