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A Study Comparing BMS-986504 in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30)

Testing new treatment for specific pancreatic cancer with genetic deletion.

Recruiting
18 years and older
All
Phase 2/3

This study is for adults with a type of pancreatic cancer called Metastatic Pancreatic Ductal Adenocarcinoma (PDAC). The study is looking at how safe and effective a drug called BMS-986504 is when used with two other cancer drugs, Nab-paclitaxel and Gemcitabine. The study will compare this treatment to a placebo (a fake treatment) with the same two cancer drugs. The study involves people who have a specific genetic change called MTAP deletion in their tumors.

Key Points:

  • The study includes people with a confirmed diagnosis of PDAC that has spread to other parts of the body.
  • Participants should not have had other cancer treatment for their metastatic cancer, except for one cycle of the study drugs.
  • People with another active cancer within the last 2 years cannot join.

Note: This study helps understand if the new treatment is safe and works better than the standard treatment, and participants must meet specific health criteria to join.

Study details
    Pancreatic Ductal Adenocarcinoma

NCT07076121

Bristol-Myers Squibb

7 March 2026

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