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A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

Study of Ifinatamab Deruxtecan for metastatic prostate cancer patients.

Recruiting
18 years and older
Male
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

Clinical Study of Ifinatamab Deruxtecan in Metastatic Prostate Cancer

This study is for men with metastatic castration-resistant prostate cancer (mCRPC), which means the cancer has spread and resists hormone treatments. Researchers are testing a new medicine called ifinatamab deruxtecan (I-DXd) to see if it can help patients live longer than traditional chemotherapy.

Eligibility: Participants must have mCRPC and show cancer progression despite hormone treatments. They should have tried 1 or 2 androgen receptor (hormone) blockers before. Those with certain lung diseases or heart problems, or those who have had specific chemotherapy, cannot join.

  • Study involves taking the new medicine, I-DXd.
  • May involve regular visits to monitor health and cancer progress.
  • Potential risks include common drug side effects and those specific to I-DXd.
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Study details
    Prostate Cancer
    Prostatic Neoplasms

NCT06925737

Merck Sharp & Dohme LLC

7 March 2026

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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