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Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)

Studying Muvalaplin's effects on heart health in adults with high Lipoprotein(a).

Recruiting
18 years and older
All
Phase 3
Study Summary: This study is exploring if a medicine called muvalaplin can help lower the risk of heart problems in people with high levels of a fat-like substance in their blood, known as lipoprotein(a). **Lipoprotein(a)**, or Lp(a), is a type of cholesterol that can increase the chance of heart attacks or strokes. **Cardiovascular disease (CVD)** refers to problems with the heart or blood vessels. Participants need to have high Lp(a) levels and either have had heart problems in the past or be at risk of having one. **Eligibility:** To join, you need Lp(a) levels of 175 nmol/L or higher and have had a past heart event or be at risk due to conditions like coronary artery disease (CAD) or diabetes. **Exclusion:** You cannot join if you've had a major heart event or surgery recently, have uncontrolled blood pressure, severe kidney issues, or certain heart failure conditions. Key Points:
  • The study involves taking the medicine muvalaplin.
  • Participants may need regular visits for check-ups.
  • There may be some risks involved, like in any medical study.
Study details
    Elevated Lp(a)
    Atherosclerotic Cardiovascular Disease (ASCVD)

NCT07157774

Eli Lilly and Company

11 April 2026

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