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Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS

Study on reducing inflammation in children with sepsis-related organ issues.

Recruiting
1-17 years
All
Phase 2/3
  • Simplified description (AI rewritten)
  • Technical description (Original)

The TRIPS study is testing a drug called anakinra in children with sepsis-induced multiple organ dysfunction syndrome (MODS). Sepsis is a severe infection that can cause organs like the heart, lungs, and kidneys to stop working properly. The study wants to see if anakinra can help reduce hyperinflammation (when the body’s immune system is overactive) in these children. The trial is double-blind (neither doctors nor patients know who gets the real drug or a placebo) and randomized (participants are chosen by chance).

Children aged between 40 weeks (after birth) to under 18 years who are in the Pediatric Intensive Care Unit (PICU) or Cardiac Intensive Care Unit (CICU) and have at least two new organ problems due to infection can join. They will receive anakinra or placebo for seven days. Some children won’t qualify, like those who weigh less than 3kg or have certain medical conditions.

  • The study lasts for 7 days.
  • Participants will be randomly given either anakinra or a placebo.
  • Close monitoring for safety and effectiveness is ensured.
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Study details
    Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)

NCT05267821

Nationwide Children's Hospital

7 March 2026

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