This study is for children with a type of kidney cancer called Wilms Tumor. The goal is to use risk factors to decide the best treatment for them. Wilms Tumor is a common kidney cancer in kids, and "favorable histology" means the cancer cells look less aggressive. The study aims to find ways to prevent the cancer from coming back after treatment. The treatments might include surgery, chemotherapy, and sometimes radiation. The study checks if some treatments are as good as past ones but with fewer side effects.

• Participation: Requires frequent visits and tests, with follow-ups for 10 years.
• Eligibility: Children under 30 years with newly diagnosed Wilms Tumor.
• Treatment: Involves different chemotherapy drugs depending on tumor stage and biology.

This study does not involve patients with Stage V Wilms Tumor. Risks include side effects from chemotherapy. It’s important for families to understand the commitment before joining. Participants will help researchers learn more about which treatments work best for different patients.