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A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease

Testing KarXT + KarX-EC for Alzheimer's cognitive symptoms.

Recruiting
60-85 years
All
Phase 3

This study looks at how safe and effective KarXT + KarX-EC is for helping people with cognitive impairment (trouble thinking and remembering) due to Alzheimer's Disease (AD). AD is a brain condition that affects memory and thinking. Participants must have mild or moderate AD and a caregiver to assist them. They should also be on stable doses of certain medications, like acetyl choline esterase inhibitors and memantine, for at least 12 weeks before joining and throughout the study. People with serious health issues or psychiatric disorders cannot join. Also, participants should not have had other treatments interfering with AD or significant brain problems on an MRI. The study will assess whether the treatment helps with thinking and memory and if it is safe for participants.

  • The study requires participants to have a caregiver who can help and attend all visits.
  • Participants must have stable medication doses before and during the study.
  • People with significant health problems or psychiatric disorders cannot join.
Study details
    Alzheimer's Disease

NCT06976216

Bristol-Myers Squibb

28 March 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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