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A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

Testing new leukemia treatments for children and young adults.

Recruiting
366-46 years
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for children, teens, and young adults with a special type of blood cancer called B-cell Acute Lymphoblastic Leukemia (B-ALL). The study looks at how well a drug called blinatumomab works when combined with another drug, either dasatinib or imatinib, plus regular chemotherapy. Blinatumomab helps the immune system fight cancer. Dasatinib and imatinib stop cancer cells from growing. The study is to see if this combination is better than usual treatments.

  • Participants will be in the study for about 2 years and will have regular check-ups and tests.
  • Potential risks include side effects from the drugs, but these will be monitored closely by doctors.
  • Participants might receive some compensation for participating and helping with this important research.

To join, patients must be younger than 25 years old and have a certain type of genetic marker in their leukemia. There are specific health requirements that need to be met. It's important to discuss with a doctor if participating is a good choice.

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Study details
    B Acute Lymphoblastic Leukemia

NCT06124157

National Cancer Institute (NCI)

13 September 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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