**Study of Obexelimab in Patients With Systemic Lupus Erythematosus** This study is for people with Systemic Lupus Erythematosus (SLE), a disease where the immune system attacks healthy cells. The study will test a drug called obexelimab. Participants will get either obexelimab or a placebo (a fake treatment) through a shot under the skin weekly for 24 weeks. A placebo is used to see if the real drug works better than nothing. Before joining, participants must have had SLE for at least 24 weeks and meet specific health criteria. **Key Points to Consider:** - The study lasts up to 40 weeks, including screening, treatment, and follow-up. - Participants need to visit the study site multiple times: at Weeks 2, 4, and every 4 weeks after. - Patients will be checked for how well the treatment works and if it's safe. Patients must not have serious kidney issues or other active diseases that might interfere with the study. They should also not have a history of certain blood clotting problems or severe brain issues.