This study is about testing a medicine called obexelimab in people with a disease called systemic lupus erythematosus (SLE). SLE is a condition where the immune system, which fights germs, attacks the body instead. The research lasts around 40 weeks, including treatment and follow-up times.

To join, you must be 18 to 70 years old, have had SLE for at least 24 weeks, and meet specific health rules. During the study, participants will get either obexelimab or a placebo (a fake treatment) through weekly injections for 24 weeks. Visits to the research site are needed at Week 2, Week 4, and every 4 weeks after.

Participants need to be on standard lupus treatments like oral corticosteroids, antimalarials, or immunosuppressants. If you have certain other health conditions, you may not be able to join. The study checks how safe and effective the medicine is and will pay attention to your health closely.

• Duration: Approximately 40 weeks.
• Visits: Regular check-ins every 4 weeks after the initial visits.
• Risks: Some health conditions may exclude participation.