**A Study for GSK3862995B in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease (COPD)** This research is looking at how safe and tolerable a medicine called GSK3862995B is. The study involves two groups: healthy people and those with Chronic Obstructive Pulmonary Disease (COPD). *COPD* is a lung disease that makes it hard to breathe. **Key Points:** - The study involves taking one dose of the medicine for healthy people and repeated doses for those with COPD. - Participants must be within certain age and weight limits and have no serious allergies or uncontrolled diseases. - People will have to visit the study site for screenings and to take the medicine, but they must not have had certain infections or cancers recently. To join, healthy participants should be between 18-65 years old, while COPD participants should be 40-75 years old. You need to have a certain body weight and not be pregnant. The study checks many things like weight, breathing tests, and medical history to make sure people are safe to join.