This study is about testing how safe and tolerable a new drug, **GSK3862995B**, is for people who are healthy and those with a lung condition called **Chronic Obstructive Pulmonary Disease (COPD)**. COPD is a disease that makes it hard to breathe. The study will give healthy people a single dose and people with COPD multiple doses. **Healthy participants** must be between 18-65 years old, with a certain weight and height range. **COPD participants** must be between 40-75 years old, have a confirmed COPD diagnosis, and have a history of smoking.

• Time Commitment: Participation involves multiple visits for people with COPD.
• Eligibility: Includes both healthy individuals and those with COPD, depending on age and health status.
• Risks: Participants with certain medical conditions or allergies are excluded for safety reasons.

Participants cannot join if they have uncontrolled medical conditions or recent infections. The study checks for allergies and past illnesses to ensure safety. If you meet the criteria and are interested, you may get to help test this new treatment for COPD.