This study is for people with long-term *Hepatitis B* (a liver infection caused by the hepatitis B virus). We are testing a new medicine, **GIGA-2339**, to see if it is safe and how it works in the body. Participants will receive the medicine through a needle in a vein (this is called an *intravenous dose*). To join, you must have been diagnosed with chronic Hepatitis B for at least 6 months and meet other requirements.

• You will need to visit the study location several times for tests and to receive the medicine.
• It’s important to follow all safety rules, like using birth control if you can have children.
• You cannot join if you have other infections like hepatitis C or HIV, or if you have serious liver issues.

The study is not for everyone, so doctors will check your health to see if you can join. If you qualify, you'll be helping researchers learn more about this possible treatment for Hepatitis B.