Image

A Study of Subcutaneously Injected Epcoritamab Plus Oral Lenalidomide Tablets Compared to Intravenously (IV) Infused Rituximab Plus IV Infused Gemcitabine and IV Infused Oxaliplatin in Adult Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Testing Epcoritamab and Lenalidomide vs. Rituximab, Gemcitabine, Oxaliplatin for Lymphoma.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for adults with a type of blood cancer called Diffuse Large B-Cell Lymphoma (DLBCL) that has come back or hasn't responded to treatment. The study is trying to find out if a new treatment with the drugs epcoritamab and lenalidomide (called E-Len) is safe and works better than the usual treatment with rituximab, gemcitabine, and oxaliplatin (R-GemOx). Epcoritamab is an experimental drug, which means it is still being tested.

Participants will be divided into three groups. Group A will get injections of epcoritamab and lenalidomide pills for up to 12 cycles, with each cycle lasting 28 days. Group B will receive R-GemOx through an IV for up to 4 cycles. Group C will get epcoritamab injections for up to 12 cycles.

During the study, participants will have to visit the hospital or clinic regularly for check-ups, blood tests, and to fill out questionnaires. The study will have about 360 participants from around the world.

  • Study lasts up to 12 months with monthly cycles.
  • Regular hospital visits are required.
  • Participants may face more treatment burden than usual care.
Print
Study details
    Diffuse Large B-Cell Lymphoma

NCT06508658

Genmab

7 March 2026

Contact a study center
Step 1 Get in touch with the nearest study center
We have submitted the contact information you provided to the research team at {{SITE_NAME}}. A copy of the message has been sent to your email for your records.
Would you like to be notified about other trials? Sign up for Patient Notification Services.
Sign up

Send a message

Enter your contact details to connect with study team

Investigator Avatar

Primary Contact

  Other languages supported:

First name*
Last name*
Email*
Phone number*
Race
Ethnicity
Other language

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.