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A Phase 1 Open-Label Study of the Safety of Intravenous Allogeneic Neonatal Mesenchymal Cells (nMSCs) in Young Adult (1A) and Pediatric (1B) Patients With Dilated Cardiomyopathy (DCM)

We are studying a new treatment for heart muscle weakness.

Recruiting
4-30 years
All
Phase 1
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study aims to see if a new treatment using special cells called allogeneic neonatal mesenchymal stromal cells (nMSCs) can help people with a heart condition called dilated cardiomyopathy (DCM). DCM is when the heart becomes enlarged and weak, making it hard to pump blood. The study will include young adults (ages 18-30) and children (ages 4-17). Participants will receive the treatment through an intravenous (IV) infusion, which means the medicine is put directly into a vein. This happens every 30 days, and there are 3 infusions total. After the last infusion, there will be several check-up visits over 14 months to see how well the treatment is working and to ensure it's safe. Participants will have tests like heart scans, blood tests, and walking tests. There's financial compensation for participating, and some visits require an overnight stay nearby.

  • Study lasts 14 months with follow-up visits.
  • Participants aged 4-30 with specific heart conditions.
  • Financial compensation and help with parking provided.
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Study details
    Dilated Cardiomyopathy

NCT06464588

Emory University

7 March 2026

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