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A Study of XMT-2056 in Advanced/Recurrent Solid Tumors That Express HER2

Research on XMT-2056 for advanced/recurrent HER2-positive tumors.

Recruiting
18 years and older
All
Phase 1

The study is about trying a new medicine called XMT-2056 for people with certain types of cancer. These are cancers that have come back or have spread and show a protein called HER2. XMT-2056 is being tested in patients who have already tried other treatments without success. This is the first time it's being used in humans, and the study will find the safest dose to use. It will also see how the medicine works against the cancer.

Key Points:

  • Length and Visits: The study has two parts: finding the right dose and testing how well it works. It may involve multiple visits.
  • Treatment and Risks: You'll receive XMT-2056 and be monitored for any side effects to find the best dose.
  • Eligibility: To join, your cancer must show HER2, and you should have tried other treatments first.

If you have another cancer needing treatment within the last 2 years or certain brain conditions, you may not be eligible. The study is open-label, meaning both doctors and patients know the treatment given. Always talk to your doctor to see if this study is right for you.

Study details
    HER2-positive Breast Cancer
    HER2-positive Gastric Cancer
    HER2-positive Non-Small Cell Lung Cancer
    HER2-positive Colorectal Cancer
    HER2-positive Tumors
    HER2 Low Breast Cancer

NCT05514717

Mersana Therapeutics

7 March 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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