This study tests a new medicine called Asimadoline (TP0052) to help women with vasomotor symptoms (VMS) like hot flashes during menopause. Menopause is when a woman's body stops having periods. VMS can be uncomfortable, causing sweating and feeling very hot. The study lasts for 14 weeks. First, participants record their symptoms daily for 2 weeks. Then, they take either the new medicine or a fake pill (placebo) for 8 weeks without knowing which one they get. After that, everyone takes the real medicine for 4 more weeks. There is a safety follow-up call after treatment.

• Participants must be women aged 40-62 experiencing moderate to severe VMS.
• Participants should not have used certain medications or supplements recently.
• The study is double-blind, meaning neither doctors nor participants know who gets the real drug initially.

Women with certain health issues, like severe heart disease or liver problems, cannot join. The study aims to see if the medicine helps reduce symptoms safely.