Asimadoline is being tested to see if it helps women experiencing vasomotor symptoms (VMS) during menopause. These are hot flashes or night sweats that can be uncomfortable. This study lasts for a total of 14 weeks. First, women will record their symptoms for 2 weeks. After that, they will take either the study drug, called asimadoline, or a placebo (a sugar pill) for 8 weeks. No one, including doctors, will know who is getting the real drug or the placebo during this time. After these 8 weeks, everyone will take asimadoline for 4 more weeks, but this time everyone knows they are getting the study drug. There will also be a safety check by phone after treatment. This study is for women aged 40-62 who have not been using other drugs for VMS. If you have certain health issues or are using certain medications, you may not be eligible.

• The study involves 14 weeks of participation, including taking medication and recording symptoms.
• Eligibility is limited to women 40-62 years, not on specific VMS treatments.
• Risks include potential side effects or interactions with existing health conditions or medications.