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Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer

Comparing lung cancer treatments before or after surgery in a clinical trial.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is looking at the best way to treat stage II-IIIB non-small cell lung cancer (NSCLC) that can be removed by surgery. The research compares two approaches: giving treatment after surgery (adjuvant therapy) versus giving treatment before and after surgery (perioperative therapy). Treatments include chemotherapy, which involves drugs like cisplatin and carboplatin, and immunotherapy using special proteins called monoclonal antibodies (like nivolumab) that help the immune system fight cancer. This study aims to see which method helps patients live longer without their cancer returning.

  • Participants are randomly assigned to one of two groups and receive treatment for up to 1 year.
  • Patients will have regular follow-ups every 6 months for up to 10 years to monitor their health.
  • Eligibility includes confirmed resectable stage II-IIIB NSCLC and being at least 18 years old.
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Study details
    Resectable Lung Non-Small Cell Carcinoma
    Stage II Lung Cancer AJCC v8
    Stage IIIA Lung Cancer AJCC v8
    Stage IIIB Lung Cancer AJCC v8

NCT06632327

Alliance for Clinical Trials in Oncology

5 July 2025

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