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Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer

Study on treatment timing for Stage II-IIIB lung cancer patients.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study looks at treating lung cancer before and after surgery. Lung cancer, specifically non-small cell lung cancer (NSCLC), can sometimes be removed by surgery. Doctors usually use chemotherapy (a treatment that uses medicine to kill cancer cells) and immunotherapy (a treatment that helps the immune system fight cancer) before or after surgery. The study aims to find out if combining these treatments before and after surgery is better than just after surgery. Chemotherapy drugs like cisplatin and carboplatin stop cancer cells from growing. Immunotherapy drugs like nivolumab help the immune system attack cancer. The study will compare how well patients do, how well surgery works, and what side effects occur. Patients will be randomly placed in one of two groups: one group receives treatment before and after surgery, and the other just after surgery. The study will follow patients for up to 10 years.

  • The study lasts up to 10 years with follow-ups every 6 months.
  • Patients may need CT, MRI, or PET scans during the study.
  • Eligibility includes being over 18 and having a certain type and stage of lung cancer.
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Study details
    Resectable Lung Non-Small Cell Carcinoma
    Stage II Lung Cancer AJCC v8
    Stage IIIA Lung Cancer AJCC v8
    Stage IIIB Lung Cancer AJCC v8

NCT06632327

Alliance for Clinical Trials in Oncology

7 March 2026

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