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JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC

Participate in a study on a new treatment for head and neck cancer.

Recruiting
60 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for people aged 60 and older with head and neck cancer (HNSCC) who can't use platinum-based chemo. The study looks at a new treatment, JNJ-90301900 (NBTXR3), combined with radiation therapy (RT) and possibly cetuximab, compared to just RT and possibly cetuximab. **JNJ-90301900** is injected directly into the tumor and then activated by RT. **Cetuximab** is a drug that helps RT work better against cancer cells.

People joining the study will have a check-up before starting to see if they can participate. If eligible, they will be randomly assigned to one of the two groups: one group will receive JNJ-90301900 with RT, and the other just RT. Both groups will have RT for 7 weeks. After treatment, check-ups will occur every 12 weeks for 2 years, then every 24 weeks.

Key Points:

  • Participation lasts for a minimum of 2 years with regular follow-up visits.
  • This study involves new treatment methods that could improve outcomes for older patients.
  • Participants must meet specific health criteria and cannot have certain other cancers or infections.
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Study details
    Locally Advanced Head and Neck Squamous Cell Carcinoma
    Aged

NCT04892173

Johnson & Johnson Enterprise Innovation Inc.

28 June 2025

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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