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A Clinical Trial to Learn About the Effects of VHB937 in People With Amyotrophic Lateral Sclerosis (ALS)

Studying VHB937's effects in people with ALS.

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for people with Amyotrophic Lateral Sclerosis (ALS), a disease that affects nerve cells in the brain and spinal cord. The trial will test a new medicine called VHB937 to see if it helps people with early-stage ALS, meaning they started having symptoms within the last two years. For 40 weeks, participants will either get VHB937 or a placebo (a pill with no medicine), without knowing which one they are getting. After that, they may continue using VHB937.

Researchers want to find out if VHB937 helps people breathe without machines for longer and improves their ability to do daily activities. They will also track any side effects, which are changes in health that happen during the study, even if they are not caused by the medicine.

  • The study lasts 40 weeks with possible continuation.
  • Participants must be 18+ and have early-stage ALS.
  • Strict contraception is required for those of childbearing potential.
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Study details
    Amyotrophic Lateral Sclerosis (ALS)

NCT06643481

Novartis Pharmaceuticals

28 June 2025

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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