This study looks at how safe and effective a new medicine, **itepekimab**, is for adults with long-term nose problems called **chronic rhinosinusitis with nasal polyps** (CRSwNP). People in this study will try two different doses of the medicine or a placebo, which is like a fake medicine. All participants will also use a nose spray called an **intranasal corticosteroid** (INCS) to help with symptoms. The study lasts up to **76 weeks**, which includes different phases: 4 weeks to start, 52 weeks of treatment, and 20 weeks of safety follow-up. Participants will have **9 in-person visits** and **20 phone or home visits**. **Key Points:**

• The study lasts up to 76 weeks; part of this time includes treatment and follow-up.
• Participants will have 9 in-person visits and 20 phone/home visits.
• It's important to be aware of personal health conditions that might prevent participation.

People need to be 18 or older and have had nose problems for at least a year. Some health issues, like severe asthma or recent smoking, might exclude a person from joining. Participants must not be allergic to the study medicine.