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Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-Related Macular Degeneration

Study on Ixo-vec for age-related macular degeneration safety and effectiveness.

Recruiting
50 years and older
All
Phase 3

Study Overview: This research focuses on people with a condition called neovascular age-related macular degeneration (nAMD). nAMD is an eye disease where unusual blood vessels grow under the retina, which can lead to vision loss. Ixo-vec, a gene therapy, aims to treat nAMD and reduce the need for frequent eye injections. In this study, participants will receive a single injection of Ixo-vec to see if it works as well as the current treatment.

  • Study Length: The main results will be checked around Weeks 52 and 56 after treatment.
  • Visits Required: Participants will need to attend multiple visits for monitoring their safety and treatment effectiveness.
  • Eligibility: Participants must be over 50, with nAMD in one eye, and meet other health criteria.

Participants should be willing to follow study guidelines and attend all scheduled visits. There are also some health conditions and treatments that might exclude a person from participating. Overall, this study hopes to find a better way to treat nAMD and maintain vision in older adults.

Study details
    Neovascular Age-Related Macular Degeneration (nAMD)
    Wet AMD

NCT06856577

Adverum Biotechnologies, Inc.

21 June 2025

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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