Image

A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer

Join a study for new lung cancer treatments.

Recruiting
18 years and older
All
Phase 3
This study is for people with a type of lung cancer called **metastatic non-small cell lung cancer (mNSCLC)**. The study compares two treatments: **rilvegostomig** and **pembrolizumab** for patients whose tumors have a protein called **PD-L1**. **PD-L1** is a protein that can help cancer hide from the immune system. **Eligibility**: Participants need to have stage IV mNSCLC, which means the cancer has spread. They must have specific tests showing no certain gene mutations, and be healthy enough to participate. **Exclusion**: People with other severe diseases, past organ transplants, or other cancers may not join. **Key Points**: - **Study Length**: Participants will be in this study for many weeks, with regular health checks. - **Visits Needed**: You will need to visit the study site multiple times for evaluations and treatments. - **Risks**: As with many cancer treatments, there may be side effects which will be monitored closely. This study aims to find out which treatment works better and is safer for patients with this specific type of lung cancer.
Study details
    Carcinoma
    Non-Small Cell Lung

NCT06868277

AstraZeneca

7 March 2026

Step 1 Get in touch with the nearest study center
We have submitted the contact information you provided to the research team at {{SITE_NAME}}. A copy of the message has been sent to your email for your records.
Would you like to be notified about other trials? Sign up for Patient Notification Services.
Sign up

Send a message

Enter your contact details to connect with study team

Investigator Avatar

Primary Contact

  Other languages supported:

First name*
Last name*
Email*
Phone number*
Race
Ethnicity
Other language

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.