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A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

Exploring lower radiation doses for treating children's brain tumors.

Recruiting
3-29 years
All
Phase 2

Study Overview: This study is testing if a lower dose of radiation therapy (RT) after chemotherapy helps treat children with a type of brain tumor called CNS germinoma. Chemotherapy involves drugs like Carboplatin and Etoposide, which help stop cancer cells from growing. Radiation therapy uses high-energy waves to kill cancer cells.

Key Points:

  • This study lasts up to 120 months with follow-up visits after treatment.
  • Patients will receive chemotherapy and then radiation therapy, with the number of sessions depending on their response to treatment.
  • Participants will have regular health checks, including MRI scans and optional blood tests.

Eligibility: Children aged 3 to under 30 with newly diagnosed CNS germinoma can participate. They must have certain medical tests done before joining. Pregnant girls or those who have had other cancer treatments (besides surgery and certain medicines) cannot join. All participants and their guardians must agree to the study rules.

Study details
    Basal Ganglia Germinoma
    Central Nervous System Germinoma
    Diabetes Insipidus
    Pineal Region Germinoma
    Suprasellar Germinoma
    Thalamic Germinoma

NCT06368817

Children's Oncology Group

7 March 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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