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A Study to Learn More About How Well Sevabertinib (BAY 2927088) Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

Exploring Sevabertinib's effectiveness and safety for advanced lung cancer.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for people with advanced non-small cell lung cancer (NSCLC) who have a special genetic change called HER2 mutation. NSCLC is a serious type of lung cancer that spreads and is hard to treat. HER2 is a protein that helps cells grow, and when it changes (mutates), it can cause cancer to grow faster. The study drug, BAY 2927088, might block this bad protein to stop cancer from spreading.

Participants will either take BAY 2927088 as a pill twice daily or receive standard treatment through a vein every 21 days. The study will monitor health with scans, blood tests, and heart checks. Doctors will also note any side effects, called adverse events.

Key Points:

  • Length & Visits: Treatment continues as long as there are benefits without severe side effects.
  • Eligibility: Must be 18+ with specific NSCLC type and HER2 mutation.
  • Risks: Possible side effects will be monitored, and safety is compared with standard treatment.
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Study details
    Advanced Non-small Cell Lung Cancer
    HER2 Mutation

NCT06452277

Bayer

7 March 2026

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