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A Phase 3, Randomized, Double-blind Study for Patients With Invasive Candidiasis Treated With IV Echinocandin Followed by Either Oral Ibrexafungerp or Oral Fluconazole

Join a study on oral treatments for invasive candidiasis.

Recruiting
18 years and older
All
Phase 3

This study is looking at two ways to treat a serious yeast infection called invasive candidiasis. It includes a yeast infection in the blood, known as candidemia. People in the study first get a medicine called IV echinocandin through their veins. Later, they take either oral ibrexafungerp (a new drug) or oral fluconazole (a common drug) by mouth. The study is randomized (like flipping a coin to decide which medicine you get) and double-blind (neither the doctor nor the participant knows which medicine is given) to ensure fairness.

  • Participants must be 18 or older and have a Candida yeast infection found in their blood or tissue.
  • Cannot join if the infection is in certain body parts, like the heart or brain, or if they've tried other antifungal medicines that didn't work.
  • The study involves multiple visits and some tests to check for side effects or other issues.

People with specific health problems, like severe liver issues or other fungal infections, should not participate. If you're interested, make sure you discuss risks and benefits with your doctor.

Study details
    Candidiasis
    Invasive
    Candidemia

NCT05178862

Scynexis, Inc.

21 June 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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