The **SPYRAL GEMINI Pilot Study** is checking if a new treatment called multi-organ denervation (MDN) is safe and can help lower high blood pressure. This study is for people with high blood pressure (hypertension) and looks at two groups: one group not taking medication and another group taking medication for high blood pressure and other heart risks. The study will help gather information for future research. **Key Points:** - Participants must be between 18 and 80 years old with specific blood pressure levels. - The study does not require a set number of visits or a primary goal but aims to collect data for future studies. - People with certain health conditions, like kidney or liver disease, cannot join. Inclusion criteria are specific blood pressure readings, while exclusion criteria include previous kidney/liver treatments, certain diabetes medications, or pregnancy. If you're considering participating, ensure you meet the age and health requirements and understand the potential risks and benefits of MDN.