This study is checking how safe and tolerable the drug **ziftomenib** is when used with other medicines, like **venetoclax** and **azacitidine** (ven/aza), in people with a type of blood cancer called **Acute Myeloid Leukemia** (AML). Participants must have specific gene changes, either **NPM1 mutation** or **KMT2A rearrangement**. The study is in **Phase 1**, which means it is one of the first stages of testing these drugs together.
- Participants may need to use contraception during the study and for a while after finishing.
- People with certain health conditions, like active infections or other cancers, cannot join.
- The study involves testing for safety and any early signs that the treatment works against AML.
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