This study is testing a new medicine called *ziftomenib* to see if it is safe and works well when combined with other drugs for people with acute myeloid leukemia (**AML**), a type of blood cancer. Researchers are looking at how *ziftomenib* works with drugs like venetoclax, azacitidine, and others in people with specific genetic changes in their cancer cells.

Participants will be grouped into different parts of the study based on their specific type of AML and if they were recently diagnosed or if their cancer has returned. The main goal is to see if *ziftomenib* is safe and how well it can help treat AML.

• Participants may need to use special protection to avoid pregnancy for several months during and after the study.
• This study is not for people with certain health conditions like active infections or specific types of leukemia.
• There are strict rules about what other treatments participants can be receiving before starting this study.