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A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)

Assessing benfotiamine's effects on early Alzheimer's safety and benefits.

Recruiting
50-89 years
All
Phase 2
This clinical trial is studying a drug called **Benfotiamine** to see if it can help people with early Alzheimer's disease. Alzheimer's is a condition that affects memory and thinking. Benfotiamine might help slow down symptoms. The study will last **18 months**, and it involves two phases: **Phase 2A** and **Phase 2B**. During Phase 2A, participants will receive either 600 mg, 1200 mg of Benfotiamine, or a **placebo** (a pill that doesn’t contain the drug) to find the best dose. Phase 2B will then test the effectiveness of the chosen dose over 72 weeks. To join, you must be between **50 and 89 years old** and have mild memory problems due to Alzheimer's. You need a buddy who can help and attend visits with you. You also need to be able to walk and speak English or Spanish. **Some medical conditions may prevent you from joining**, like other serious brain diseases or uncontrolled diabetes. **Key Points:** - **Duration**: 18 months with multiple visits. - **Eligibility**: Ages 50-89, early Alzheimer's symptoms. - **Participation**: Must have a study partner and be able to attend visits.
Study details
    Alzheimer Disease

NCT06223360

Alzheimer's Disease Cooperative Study (ADCS)

7 March 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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