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A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)

Testing Benfotiamine for safety in early Alzheimer's patients.

Recruiting
50-89 years
All
Phase 2
This study aims to test the safety and effectiveness of a drug called **Benfotiamine** on people with early Alzheimer's Disease (AD). **Early Alzheimer's Disease** is a brain disorder that affects memory and thinking. The study lasts for 18 months (1.5 years) and involves 406 participants. It's a **double-blind** trial, meaning neither the participants nor the researchers know who gets the actual drug or a placebo (a fake treatment). Benfotiamine will be tested in two doses: 600 mg or 1200 mg per day. The study's first phase (phase 2A) will find the safest dose, and the second phase (phase 2B) will test how well it works over 72 weeks. Participants need to be between the ages of 50 and 89 and have mild memory problems. They also need a study partner who will help them with the study requirements. - **Participation involves regular visits to the clinic over 72 weeks.** - **Participants must not have any major health issues other than early AD.** - **Previous exposure to Benfotiamine or participation in other trials may disqualify you.** This study could help find new ways to slow down memory loss in Alzheimer's patients.
Study details
    Alzheimer Disease

NCT06223360

Alzheimer's Disease Cooperative Study (ADCS)

7 June 2025

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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