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Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer

Study on how lymph node mapping affects leg function in early endometrial cancer.

Recruiting
18 years and older
Female
Phase 3

This study looks at two ways of checking lymph nodes during a hysterectomy for stage I endometrial cancer to see which way is better at preventing leg swelling, also known as lymphedema. **Sentinel lymph node mapping** uses a special dye and a camera to find lymph nodes where cancer might have spread. **Standard lymph node dissection** involves removing more lymph nodes to check for cancer. The goal is to find out which method leads to less leg swelling.

Key Points:

  • The study lasts two years, with follow-up visits every three months initially, then at 18 and 24 months.
  • Participants will receive a dye injection and either type of lymph node checking during surgery.
  • Eligibility requires being 18 or older, with stage I endometrial cancer, and speaking English or Spanish.

Participants need to agree to the study and can’t have certain health issues or have had treatments that might interfere with the study. This research helps doctors understand which method is safer and more effective for patients undergoing surgery for endometrial cancer.

Study details
    Stage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8

NCT05646316

NRG Oncology

31 May 2025

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