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Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer

Study on lymph node mapping's effect on leg function in early endometrial cancer.

Recruiting
18 years and older
Female
Phase 3
This study is about **endometrial cancer**, which is a type of cancer that starts in the lining of the uterus. Researchers want to see if a special technique called *sentinel lymph node mapping* can help reduce *lymphedema* (swelling in the legs) after a *hysterectomy* (surgery to remove the uterus). In this study, patients will be divided into two groups. One group will have sentinel lymph node mapping, which uses a special dye to find important lymph nodes, and the other will have standard lymph node removal. Both methods aim to check if cancer has spread. - **Length & Visits**: Patients will be followed for up to 2 years, with check-ups every 3 months in the first year, and again at 18 and 24 months. - **Procedures**: Involves ICG dye injection for mapping, possibly removing lymph nodes, and optional blood sample collection. - **Participation**: Participants must be 18+, have stage I endometrial cancer, and be able to understand English or Spanish. This study will help doctors know if this mapping technique is better for preventing leg swelling after surgery.
Study details
    Stage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8

NCT05646316

NRG Oncology

7 March 2026

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