This study aims to find the best dose of a new medicine, QCZ484, for people with mild to moderate high blood pressure (hypertension). It compares QCZ484 with a placebo (a harmless pill with no treatment) given as a shot under the skin every 6 months. This is a Phase 2b study, meaning it is still testing how well the medicine works and its safety. The study is "double-blind," so neither the doctors nor the patients know who gets the real medicine or the placebo, which helps ensure fair results.

• **Length**: The study requires a 4-week period without current hypertension medication.
• **Eligibility**: You can join if you're 18-75 years old and have mild to moderate hypertension.
• **Risks**: Participants with heart issues or liver problems may not be eligible.

To join, you need to sign a consent form and must not have certain conditions like a history of heart failure or recent heart attacks. Make sure you understand and follow the study rules. This study will help determine if QCZ484 is safe and effective for controlling high blood pressure.