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Open-label of Loncastuximab Tesirine (ADCT-402) in Relapsed/Refractory Marginal Zone Lymphoma

Participate in a study of Loncastuximab Tesirine for certain lymphoma cases.

Recruiting
18 years and older
All
Phase 2

This study looks at loncastuximab tesirine, a medicine being tested for certain types of cancer in immune cells. The aim is to see if it helps people with a specific kind of lymphoma (a blood cancer) called Marginal Zone Lymphoma (MZL), which has returned or hasn't responded to other treatments. The study will examine both the good and bad effects this treatment might have.

  • Participants will need to meet specific health criteria and be over 18 years old.
  • They should be prepared to provide tissue or bone marrow samples for testing.
  • Men and women must agree to avoid pregnancy during and for several months after the study.

People with certain other medical conditions or who have had specific treatments recently might not be eligible. Participants will be monitored for their health and response to the treatment. This study is important for finding new ways to treat MZL, but it requires commitment and carries some risks.

Study details
    Marginal Zone Lymphoma

NCT05296070

University of Miami

7 March 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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