The **StrokeNet Thrombectomy Endovascular Platform (STEP)** study is being conducted at 38 centers across the U.S. to improve care for patients with an **acute ischemic stroke (AIS)**, which is a type of stroke where blood flow to the brain is blocked. The study focuses on patients with **large (LVO) or medium vessel occlusions (MVO)**, meaning large or medium blood vessels in the brain are blocked. The trial tests different treatments like new medical devices and therapies to see which works best. Researchers use a special plan called a **Master Protocol** to guide their work and adjust as they learn more. To join, participants must have a suspected stroke and a likely blocked large or medium vessel and cannot have certain medical conditions or be in prison. The study is flexible and adapts as new interventions are introduced.

• Participants need to be 18 years or older and seen within 24 hours of stroke.
• Each domain may have extra criteria to meet.
• Involves frequent check-ups and imaging tests.

Make sure to discuss with your doctor if you meet the eligibility requirements and the potential benefits and risks involved.