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Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

Exploring Olaparib, with/without Bevacizumab, for treating ovarian cancer.

Recruiting
18 years and older
All
Phase 3

This study is testing a medicine called olaparib for one or two years, with or without another medicine called bevacizumab, to treat ovarian cancer. Ovarian cancer happens in the ovaries, a part of the female body. Olaparib helps stop tumor cells from growing, while bevacizumab blocks blood vessels that help tumors grow. The study wants to see if taking these medicines can help people with a specific kind of ovarian cancer, called BRCA-mutated or HR-deficient ovarian cancer, live longer without the cancer growing back.

Key Points:

  • Participants will be randomly assigned to take olaparib for either one year or two years.
  • Some may also receive bevacizumab for one year, along with regular check-ups and scans.
  • After the study treatment, follow-up visits will occur every 3 to 6 months for up to 5 years.
Study details
    Fallopian Tube Endometrioid Adenocarcinoma
    Fallopian Tube High Grade Serous Adenocarcinoma
    FIGO Stage III Ovarian Cancer 2014
    FIGO Stage IV Ovarian Cancer 2014
    Ovarian Carcinoma
    Ovarian High Grade Endometrioid Adenocarcinoma
    Ovarian High Grade Serous Adenocarcinoma
    Primary Peritoneal Endometrioid Adenocarcinoma
    Primary Peritoneal High Grade Serous Adenocarcinoma

NCT06580314

NRG Oncology

25 May 2025

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