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Venetoclax Basket Trial for High Risk Hematologic Malignancies

Join our Venetoclax trial for certain high-risk blood cancers.

Recruiting
1-40 years
All
Phase 1
  • Simplified description (AI rewritten)
  • Technical description (Original)

Venetoclax Basket Trial for High Risk Blood Cancers

This clinical study is testing a drug called venetoclax to see if it's safe to use with chemotherapy for young patients with certain blood cancers. These cancers include myelodysplastic syndrome (MDS), acute myeloid leukemia from MDS (MDS/AML), and acute lymphoblastic leukemia (ALL). The goal is to find the safest dose of venetoclax that can be combined with other cancer drugs. The drug works by blocking a protein in cancer cells that helps them survive.

  • The study is divided into two parts: the first part determines the dose, and the second part tests that dose.
  • Participants will have regular check-ups and treatment sessions.
  • This is a Phase I trial, meaning the drug is still being researched and not fully approved for children yet.

Participants must meet certain health requirements and should not have certain infections or conditions. Pregnant or nursing women cannot participate, and contraceptive use is necessary during the study.

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Study details
    Myelodysplastic Syndromes
    de Novo
    Myelodysplastic Syndromes
    Secondary
    Myelodysplastic Syndromes
    Previously Treated
    Treatment-Related Acute Myeloid Leukemia
    Therapy-Related Myelodysplastic Syndrome
    Acute Lymphoblastic Leukemia
    in Relapse
    Acute Lymphoblastic Leukemia With Failed Remission
    Lymphoblastic Lymphoma
    in Relapse
    Lymphoblastic Lymphoma
    Refractory
    Acute Leukemia of Ambiguous Lineage in Relapse
    Acute Leukemia of Ambiguous Lineage

NCT05292664

Andrew E. Place, MD

31 May 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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